▶ 학력

- 연세대학교 대학원 의공학과 졸업(공학박사)

▶ 경력

- 2018.09 – 2021.03 고려대학교 BK21Plus 스마트 모빌리티 교육연구팀 연구교수

▶ 연구업적

[학술논문]

- Seongjae Jo, Wonseok Lee†, Joohyung Park, Hyunjun Park, Minwoo Kim, Woochang Kim, Junghwa Hong and Jinsung Park, “Wide-range direct detection of 25-hydroxyvitamin D3 using polyethylene-glycol-free gold nanorod based on LSPR aptasensor” Biosensors and Bioelectronics (2021) (공동1저자)

- Dongtak Lee, Dongsung Park, Insu Kim, Sang Won Lee, Wonseok Lee, Kyo Seon Hwang, Jeong Hoon Lee, Gyudo Lee, and Dae Sung Yoon, “Plasmonic nanoparticle amyloid corona for screening Aβ oligomeric aggregate-degrading drugs” Nature Communications (2021) 

- Woochang Kim, Chihyun Kim, Wonseok Lee, Jinsung Park, and Duckjong Kim, “Innocuous, Highly Conductive, and Affordable Thermal Interface Material with Copper-Based Multi-Dimensional Filler Design” Biomolecules (2021) 

- Hyunjun Park, Woong Kim, Minwoo Kim, Gyudo Lee, Wonseok Lee*, and Jinsung Park, “Eco-friendly and enhanced colorimetric detection of aluminum ions using pectin-rich apple extract-based gold nanoparticles” Spectrochemica Acta Part A: Molecular and Biomolecular Spectroscopy (2021) (공동교신저자)

- Sang Won Lee, Wonseok Lee, Insu Kim, Dongtak Lee, Dongsung Park, Woong Kim, Jinsung Park, Jeong Hoon Lee, Gyudo Lee, and Dae Sung Yoon, “Bio-Inspired Electronic Textile Yarn-Based NO2 Sensor Using Amyloid−Graphene Composite” ACS Sensors (2021) 

- Minwoo Kim, Wonseok Lee,†  Joohyung Park, Woong Kim, Seongjae Jo, Woochang Kim, Chihyun Kim, Hyunjun Park, Gyudo Lee, Jinsung Park, “Advanced tracking system of multiple Artemia and various behavioral endpoints for ecotoxicological analysis”, Ecological Indicators (2020) (공동1저자)

- Woong Kim, Wonseok Lee,† Hyunsung Choi, Gyudo Lee, Jongsang Son, Sang Won Lee, Joohyung Park, Woochang Kim, Minwoo Kim, Dae Sung Yoon, Doyeon Bang, Sungsoo Na, Jinsung Park, “Bioinspired Micro Glue Threads Fabricated by Liquid Bridge-to-Solidification as an Effective Sensing Platform”, ACS Sensors (2020) (공동1저자)

- Seongjae Jo, Wonseok Lee,† Joohyung Park, Woong Kim, Woochang Kim, Gyudo Lee, Heon-Jeong Lee, Junghwa Hong, Jinsung Park, “Localized surface plasmon resonance aptasensor for the highly sensitive direct detection of cortisol in human saliva”, Sensors and Actuators B: Chemical (2020). (공동1저자)

- Joohyung Park, Wonseok Lee,†, Gyudo Lee, Hyunsung Choi, Minwoo Kim, Woong Kim, Sungsoo Na, and Jinsung Park, “Electrochemical Amyloid-Based Biosensor for the Determination of Metal Ions”, Journal of The Electrochemical Society (2019) (공동1저자)

- Joohyung Park, Wonseok Lee,† Insu Kim, Seongjae Jo, Woong Kim, Minwoo Kim, Hyunjun Park, Gyudo Lee, Wonjoon Choi, Dae Sung Yoon, and Jinsung Park, “Ultrasensitive detection of fibrinogen using red blood cell membrane draped-electrochemical impedance biosensor” Sensors and Actuators B: Chemical (2019). (공동1저자)

- Hyunsung Choi, Wonseok Lee,†, Gyudo Lee, Dae Sung Yoon, and Sungsoo Na, “The Formation Mechanism of Segmented Ring-Shaped Aβ Oligomers and Protofibrils”, ACS Chemical Neuroscience (2019). (공동1저자)

- Seongjae Jo, Insu Kim, Wonseok Lee,† Minwoo Kim, Joohyung Park, Gyudo Lee, Dae Sung Yoon, and Jinsung Park “Highly sensitive and wide-range nanoplasmonic detection of fibrinogen using erythrocyte membrane-blanketed nanoparticles” Biosensors and Bioelectronics (2019). (공동1저자) 

- Heekyeong Park, Hyungbeen Lee, Seok Hwan Jeong, Eunjin Lee, Wonseok Lee, Na Liu, Dae Sung Yoon, Sunkook Kim, Sang Woo Lee, “MoS2 field-effect transistor-Amyloid-β1-42 hybrid device for signal amplified detection of MMP-9”, Analytical Chemistry (2019). 

- Sang Won Lee, Wonseok Lee,† Dongtak Lee, Yeseong Choi, Woong Kim, Jinsung Park, Jeong Hoon Lee, Gyudo Lee, and Dae Sung Yoon, “A simple and disposable carbon adhesive tape-based NO2 gas sensor” Sensors and Actuators B: Chemical (2018). (공동1저자)

- Kyoung-Ran Kim, Dohyeon Hwang, Juhyeon Kim, Chang-Yong Lee, Wonseok Lee, Dae Sung Yoon, Dongyun Shin, Sun-Joon Min, Ick Chan Kwon, Hak Suk Chung, and Dae-Ro Ahn, “Streptavidin-mirror DNA tetrahedron hybrid as a platform for intracellular and tumor delivery of enzymes” Journal of Controlled Release (2018). 

- GeonHui Lee, Jaeho Lim, JiSoo Park, Wonseok Lee, Dae Sung Yoon, Soo Hyun Kim, Myung-Ki Kim, Sang-Hoon Lee, and Dong-Hwee Kim, “Construction of neurospheroids via surface modified concave microwells” Journal of Industrial and Engineering Chemistry (2018). 

 - Wonseok Lee, Yeseong Choi, Sang Won Lee, Insu Kim, Dongtak Lee, Yoochan Hong, Gyudo Lee, and Dae Sung Yoon, “Microwave-induced formation of oligomeric amyloid aggregates” Nanotechnology (2018). 

- Dahye Jeong, Jinsik Kim, Myung-Sic Chae, Wonseok Lee, Seung-Hoon Yang, YoungSoo Kim, Seung Min Kim, Jin San Lee, Jeong Hoon Lee, Jungkyu Choi, Dae Sung Yoon, and Kyo Seon Hwang, “Multifunctionalized reduced graphene oxide biosensors for simultaneous monitoring of structural changes in amyloid-β 40” Sensors (2018). 

- Gyudo Lee, Wonseok Lee, Seunghyun Baik, Yong Ho Kim, Kilho Eom, and Taeyun Kwon, “Correlation between the hierarchical structures and nanomechanical properties of amyloid fibrils” Nanotechnology (2018). 

- Sang Won Lee, Wonseok Lee, Yoochan Hong, Gyudo Lee, and Dae Sung Yoon, “Recent advances in carbon material-based gas sensor” Sensors and Actuators B: Chemical (2018). 

- Wonseok Lee,† Jongsang Son, Seonghyun Kim, Dongmin Yang, Seungyeop Choi, Rodrigo Akira Watanabe, Kyo Seon Hwang, Sang Woo Lee, Gyudo Lee, and Dae Sung Yoon, “Adhesive Leaf Created by a Corona Discharge” Scientific Reports (2018). (공동1저자)

- Hyungbeen Lee, Sang Won Lee, Gyudo Lee, Wonseok Lee, Kihwan Nam, Jeong Hoon Lee, Kyo Seon Hwang, Jaemoon Yang, Hyeyoung Lee, Sangsig Kim, Sang Woo Lee, and Dae Sung Yoon, “Identifying DNA mismatches at single-nucleotide resolution by probing individual surface potentials of DNA-capped nanoparticles” Nanoscale (2018). 

- Wonseok Lee,† Sang Won Lee, Gyudo Lee, and Dae Sung Yoon, “Atomic force microscopy analysis of EPPS-driven degradation and re-formation of β-amyloid aggregates” Journal of Alzheimer’s Disease Reports (2018).

- Wonseok Lee,† Hyungbeen Lee, Yeseong Choi, Kyo Seon Hwang, Sang Woo Lee, Gyudo Lee, and Dae Sung Yoon, “Nanoelectrical characterization of amyloid-β42 aggregates via Kelvin probe force microscopy” Macromolecular Research (2017). (공동1저자)

- Wonseok Lee, Insu Kim, Sang Won Lee, Hyungbeen Lee, Gyudo Lee, Sangsig Kim, Sang Woo Lee, and Dae Sung Yoon, “Quantifying L-ascorbic acid-driven inhibitory effect on amyloid fibrillation” Macromolecular Research (2016). 

- Hyungbeen Lee, Sang Won Lee, Gyudo Lee, Wonseok Lee, Jeong Hoon Lee, Kyo Seon Hwang, Jaemoon Yang, Sang Woo Lee, Dae Sung Yoon, “Kelvin probe force microscopy of DNA-capped nanoparticles for single-nucleotide polymorphism detection” Nanoscale (2016). 

- Hyungbeen Lee, Wonseok Lee,† Jeong Hoon Lee, and Dae Sung Yoon, “Surface potential analysis of nanoscale biomaterials and devices using Kelvin probe force microscopy” Journal of Nanomaterials (2016). (공동1저자) 

- Gyudo Lee, Wonseok Lee, Hyungbeen Lee, Chang Young Lee, Kilho Eom, and Taeyun Kwon, “Self-assembled amyloid fibrils with controllable conformational heterogeneity” Scientific Reports (2015). 

- Wonseok Lee,† Huihun Jung, Myeonggu Son, Hyungbeen Lee, Tae Joon Kwak, Gyudo Lee, Chi Hyun Kim, Sang Woo Lee, Dae Sung Yoon, “Characterization of the regrowth behavior of amyloid-like fragmented fibrils decomposed by ultrasonic treatment” RSC Advances (2014). 

- Gyudo Lee, Wonseok Lee, Hyungbeen Lee, Sang Woo Lee, Dae Sung Yoon, Kilho Eom and Taeyun Kwon, “Mapping the surface charge distribution of amyloid fibril” Applied Physics Letters (2012).

[연구과제]

- 2019.03 – 2022.02 : 수계 내 독성 물질 (수은, 카드뮴, 미세 플라스틱 등) 검출을 위한 아밀로이드 독성 응집체 기반 전기화학센서 및 독성 모니터링 시스템 개발, 한국연구재단

[특허]

-  METHOD AND SYSTEM FOR DETERMINING MALIGNANT MELANOMA BY USING SCANNING PROBE MICROSCOPY, Korean patent pending No. 1019679160000 (Apr 04, 2019).

-  Method for measurement of binding forces between biomaterials and proteins using dielectrophoresis force spectroscopy, Korean patent pending No. 1020170110905 (Aug 31, 2017).

-  Method for nanoparticle based highly sensitive multiple detection of gene mutation using Kelvin Probe Force Microscopy, Korean patent pending No. 1020160018283 (Feb 17, 2016).

-  Apparatus for obtaining high resolution image by synthesizing a plurality of captured image and method thereof, Korean patent pending No. 1020150122788 (Aug 31, 2015).

-  Pharmaceutical composition for treating or preventing neurodegenerative disease containing Ascorbic acid or pharmaceutically acceptable salts thereof as an active ingredient, Korean patent pending No. 1020150122306 (Aug 31, 2015).

-  Method for measuring a size of specimen using image from atomic force microscope, Korean patent pending No. 1020150027745 (Feb 27, 2015).

-  Circulating tumor cell specific protein detection method and sensor system using atomic force microscopic cantilever, Korean patent pending No. 1020150028443 (Feb 27, 2015).

-  High-throughput detection method for single-to-multiple nucleotide mutations based on nanoparticle-DNA corona complex via Kelvin probe force microscopy, Korean patent pending No. 1020150028447 (Feb 27, 2015).

-  Method for decomposition or regrowth in axial direction of amyloid fibrils by ultrasonication, Korean patent pending No. 1020150017641 (Feb 04, 2015).

-  Bio-molecule detection method and system by automatic recording of resonant frequency shift based real-time recognition of bio molecular interaction, Korean patent pending No. 1020140111516 (Aug 26, 2014).

-  Method for synthesis and conformation control of protein fibrils using polymerase chain reaction machine, Korean patent pending No. 1020140022671 (Feb 26, 2014).

[학술저서]

- Wonseok Lee et al. “Chapter 3. Advances in AFM imaging applications for characterizing the biophysical properties of amyloid fibrils” in Exploring New Findings on Amyloidosis (InTech, Croatia) (Date: Aug 24, 2016) (ISBN 978-953-51-2619-5). Most download chapter in this book.