󰋼 학력

- 2017 – 2021 : 중앙대학교 생명과학과 박사 

- 2015 – 2017 : 중앙대학교 생명과학과 석사 

- 2009 – 2015 : 가톨릭대학교 생명공학과 학사

󰋼 경력 

- 2025 – 현재 : 한국교통대학교 조교수 

- 2022 – 2025 : 대구경북첨단의료산업진흥재단 신약개발지원센터 연구원 

- 2021 – 2021 : 중앙대학교 생명과학과 박사 후 연구원 

󰋼 연구업적 

[논문] 

1. Li, Y., Zhao, C., Zhuang, Z., Moon, U.K., Park, J., Choi, E.H., Min, S., Jiang, G. (2024) Effect of chitooligosaccharide on the binding domain of the SARS-COV-2 receptor. Int. J. Biol. Mac. 278. 

2. Choi, E.H., Kim, M.H., and Park, S.J* (2024) Targeting Mitochondrial dysfunction and reactive oxygen species for neurodegenerative diseases treatment. Int. J. Mol. Sci. 25, doi: 10.3390/ijms25147952. 

3. Park, S.J., Park S.J., and Choi, E.H* (2024) Synergistic combination of RAD51-SCR7 enhances HR-repair system and improves CRISPR-Cas9 genome editing efficiency by preventing R-loop accumulation. Molecular Therapy Nucleic Acids 35, doi: 10.1016/j.omtn.2024. 102274 

4. Joo, J.H., Hong, S., Higashide, M.T., Choi, E.H., Yoon, S., Lee, M.S., Kang, H.A., Shinohara, A., Kleckner, N., Kim, K.P. (2024) RPA interacts with Rad52 to promote meiotic crossover and noncrossover recombination. Nucleic Acids Research 52, 3794-3809 

5. Choi, E.H., Park, S.J. (2023) TXNIP: A key protein in cellular stress response pathway and a potential therapeutic target. Experimental & Molecular Medicine. 55, 1348-1356. 

6. Park, S.J., Yoon, S., Choi, E.H., Hyeon, H., Lee, K., Kim, K.P. (2023) Elevated expression of exogenous RAD51 enhances the CRISPR/Cas9-mediated genome editing efficiency. BMB reports. 56, 102-107. 

7. Yoon, S., Choi, E.H., Kim, K.P. (2023) The a-kleisin subunits of cohesin preserves the genome integrity of embryonic stem cells. BMB reports. 56, 108-113. 

8. Koh, Y.E., Choi, E.H., Kim, K.P. (2022) The kleisin subunits of cohesin involve in the fate determination of embryonic stem cells. Mol. Cells. 45, 820-832. 

9. Choi, E.H., Yoon, S., Koh, Y.E., Hong, T.K., Do, J.T., Lee, B.K., Hahn, Y., Kim, K.P. (2022) Meiosis-specific cohesin complexes display essential and distinct roles in mitotic embryonic stem cell chromosomes. Genome Biology 3;23(1):70. doi: 10.1186/s13059-022-02632. 

10. Choi, E.H., Yoon, S., Koh, Y.E., Seo, Y.J., Kim, K.P. (2020) Maintenance of genome integrity and active homologous recombination in embryonic stem cells. Experimental & Molecular Medicine 52, 1220-1229. 11. Jin, H*., Lee, B*., Luo, Y., Choi, Y., Choi, E.H., Jin, H., Kim, K.B., Seo, S.B., Kim, Y.H., Lee, H.H., Kim K.P., Lee, K., Bae, J. (2020) FOXL2 directs DNA double-strand break repair pathways by differentially interacting with Ku. Nature Communications, 24, 10.1038/s41467-020-15748-1. 

12. Choi, E.H., Kim, K.P. (2019) E2F1 facilitates DNA break repair by localizing to break sites and enhancing the expression of homologous recombination factors. Experimental & Molecular Medicine 51, 1-12. 

13. Choi, E.H., Yoon, S., Kim, K.P. (2018) Combined Ectopic Expression of Homologous Recombination Factors Promotes Embryonic Stem Cell Differentiation. Molecular Therapy 26, 1154-1165. 

14. Yoon, S., Choi, E.H., Kim, J.W., Kim, K.P. (2018) Structured illumination microscopy imaging reveals localization of replication protein A between chromosome lateral elements during mammalian meiosis. Experimental & Molecular Medicine 50, 1-12. 

15. Choi, E.H., Yoon, S., Park, K.S., Kim, K.P (2017) The homologous Recombination Machinery Orchestrates Post-replication DNA Repair During Self-renewal of Mouse Embryonic Stem Cells. Scientific Reports, 7, 1-.21 

16. Choi, E.H., Yoon, S., Hahn, Y., Kim, K.P (2017) Cellular Dynamics of Rad51 and Rad54 in Response to Postreplicative Stress and DNA Damage in HeLa Cells. Molecules and Cells 40, 143-150 

17. Hong, S., Choi, E.H., Kim, K.P. (2015) Ycs4 is Required for Efficient Double-Strand Break Formation and Homologous Recombination During Meiosis. Journal of Microbiology and Biotechnology 25, 1026-1035.

[연구과제] 

1. 2025-2026 차세대 CRISPR-Cas9 기반 타깃 유전자 분해 기술 개발 (과학기술정보통신부-주관) 

2. 2024-2025 정밀 유전자교정 동시 제어 기술 활용 HTS 평가 플랫폼 구축 연구 (과학기술정보통신부-연구책임) 

3. 2023-2026 난치성 유전질환 치료를 위한 HDR 활성 정밀 유전자교정 기술 연구 (과학기술정보통신부-연구책임) 

4. 2021-2024 배아줄기세포의 코헤신복합체 조절을 통한 유전질환 억제 기전 연구 (교육부-연구책임) 

5. 2019-2021 배아줄기세포의 유전자 수선 단백질 조절을 통한 유전체 안정성 유지 기전 연구 (교육부-연구책임) 

[특허] 

1. 신규 Rheb 활성 억제제를 포함하는 결절성경화증 치료용 약학적 조성물. 2024.11.26. (특허출원)

2. CRISPR-Cas9 기반 동시 유전자교정 시스템을 이용한 암 질환 예방 또는 치료방법 2024.05.07. (특허출원) 

3. CRISPR-Cas9 시스템을 이용한 유전자교정 효율 증진 방법 2024.03.06. (특허출원) 

4. 동물세포의 유전자교정을 위한 CRISPR-Cas9 백터 개발 2022.03.18. (특허출원) 

5. REC8 유전자의 과발현을 통한 배아줄기세포 분화 효율 증진 기술 2024.09.12. (특허등록) 

6. 줄기세포 분화 효율 촉진 기술 2021.03.16. (특허등록)